Strengthen regular attacks
The source wiki advises building toward effects that help the attacks and actions you use most often in dungeon rooms. It recommends improving frequently used skills before choosing narrow bonuses that rarely affect a clear.
Plan for longer fights
Choose upgrades that remain useful when enemies take longer to defeat. The source points to damage and critical-hit upgrades for faster clears, while defense and movement upgrades may help if you take too much damage while learning bosses.
Keep the tree aligned
Skill choices should support your main weapon and trait rather than pull the build in unrelated directions. Review the choices after a major weapon or trait change. Exact node names, costs and unlock levels are not established by the source material.